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Nevertheless, further research is required to concur that.. Baroreflex activation therapy secure, effective for symptomatic advanced center failure patients Outcomes of a clinical trial announced today in the American University of Cardiology Annual Scientific Program show a new kind of therapy is effective and safe for symptomatic advanced center failure patients who already are receiving optimum medication and device therapy. The analysis also released in the Journal of the American University of Cardiology Heart Failing. The extensive research team led by Dr. William Abraham, director of the Division of Cardiovascular Medication at The Ohio Condition University Wexner INFIRMARY, examined whether carotid baroreflex activation therapy could safely improve symptoms, workout quality and capability of life in individuals with NYHA Course III heart failure.