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Nevertheless, inter – and intra-tumor heterogeneity pose a substantial problem to maximizing therapeutic efficacy. Within an individual patient, different malignancy cells may possess different units of mutations rendering it very hard to detect all the relevant mutations in one cells biopsy. Inostics' BEAMing technology may offer doctors a real-period composite picture of all mutations across all tumors in virtually any given individual using only a simple bloodstream sample , George D. Demetri , M.D., Director of the Ludwig Middle at Dana-Farber Malignancy Institute and Harvard Medical College in Boston, Mass., said. Demetri identifies data from a sub-analysis of the stage III GIST-Regorafenib in Progressive Desease trial, made to measure the efficacy of regorafenib in individuals with GIST.