Hardening of the arteries, known as atherosclerosis also, is the number one cause of heart disease and can lead to heart attack, stroke, and loss of life. In the April 9 issue of the Journal of the American Medical Association Email address details are published sildalis . Nabel, M.D., NHLBI director. For the very first time, we have evidence that aggressively reducing LDL cholesterol and blood pressure can actually reverse harm to the arteries in middle-aged adults with diabetes. All participants were American Indians 40 years or older who had diabetes, high bloodstream cholesterol, and high blood pressure but no recent history of coronary attack or other proof heart disease.